Multiple sequence alignment (MSA) lies at the heart of comparative genomics, structural biology and evolutionary inference. By arranging three or more nucleotide or amino acid sequences in a matrix, ...
With the success of structural biology and the advancements in deep-learning-based structure predictions, rapid and accurate structural comparisons among macromolecular structures have become ...
Historical introduction and overview -- Collecting and storing sequences in the laboratory -- Alignment of pairs of sequences -- Introduction to probability and statistical analysis of sequence ...
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